Agency for Toxic Substances and Disease Registry (ATSDR). ToxFAQs for Chlorine Dioxide and Chlorite. September . Available at: https://www.atsdr.cdc.gov/toxfaqs/tfacts160.pdf. Accessed on May 4, .
If you are looking for more details, kindly visit our website.
Ames RG, Stratton JW. Effect of chlorine dioxide water disinfection on hematologic and serum parameters of renal dialysis patients. Arch Environ Health. Sep-Oct;42(5):280-5. View abstract.
Arellano-Gutiérrez G, Aldana-Zaragoza EH, Pérez-Fabián A. Intestinal perforation associated with chlorine dioxide ingestion: an adult chronic consumer during COVID-19 pandemic. Clin J Gastroenterol. Dec;14(6):-60. View abstract.
Burke D, Zakhary B, Pinelis E. Acute Hemolysis Following an Overdose of Miracle Mineral Solution in a Patient With Normal Glucose-6-Phosphate Dehydrogenase Levels. Chest. ;146(4_MeetingAbstracts):273A.
Erovic Ademovski S, Lingström P, Renvert S. The effect of different mouth rinse products on intra-oral halitosis. Int J Dent Hyg. May;14(2):117-23. View abstract.
FDA. Danger: Don't Drink Miracle Mineral Solution or Similar Products. Available at: https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products?utm_campaign=FDA%20warns%20consumers%20about%20the%20dangerous%20and%20potentially%20life%20threatening&utm_medium=&utm_source=Eloqua. Accessed on May 4, .
Frascella J, Gilbert R, Fernandez P. Odor reduction potential of a chlorine dioxide mouthrinse. J Clin Dent. ;9(2):39-42. Clinical Trial. View abstract.
Frascella J, Gilbert RD, Fernandez P, Hendler J. Efficacy of a chlorine dioxide-containing mouthrinse in oral malodor. Compend Contin Educ Dent. Mar;21(3):241-4, 246, 248 passim; quiz 256. Clinical Trial. View abstract.
Kerémi B, Márta K, Farkas K, et al. Effects of chlorine dioxide on oral hygiene - a systematic review and meta-analysis. Curr Pharm Des. ;26(25):-25. View abstract.
Kishan H. Chlorine dioxide-induced acute hemolysis. J Med Toxicol. Sep;5(3):177. View abstract.
Lardieri A, Cheng C, Jones SC, McCulley L. Harmful effects of chlorine dioxide exposure. Clin Toxicol (Phila). May;59(5):448-9. View abstract.
Lee SS, Suprono MS, Stephens J, Withers SA, Oyoyo U, Li Y. A randomized, blinded, clinical investigation of breath odor reduction efficacy of a stabilized chlorine-dioxide containing flavored mouthwash. Am J Dent. Aug;34(4):195-200. View abstract.
Loh JM, Shafi H. Kikuchi-Fujimoto disease presenting after consumption of 'Miracle Mineral Solution' (sodium chlorite). BMJ Case Rep. Nov 24;:bcr. View abstract.
Lubbers JR, Chauhan S, Miller JK, Bianchine JR. The effects of chronic administration of chlorine dioxide, chlorite and chlorate to normal healthy adult male volunteers. J Environ Pathol Toxicol Oncol. Jul;5(4-5):229-38. View abstract.
Medina-Avitia E, Tella-Vega P, García-Estrada C. Acute kidney injury secondary to chlorine dioxide use for COVID-19 prevention. Hemodial Int. Oct;25(4):E40-E43. View abstract.
Mohammad AR, Giannini PJ, Preshaw PM, Alliger H. Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: an open study. Int Dent J. Jun;54(3):154-8. View abstract.
Moore GS, Calabrese EJ, Ho SC. Groups at potentially high risk from chlorine dioxide treated water. J Environ Pathol Toxicol. Sep;4(2-3):465-70. View abstract.
Olin AC, Granung G, Hagberg S, et al. Respiratory health among bleachery workers exposed to ozone and chlorine dioxide. Scand J Work Environ Health. Apr;28(2):117-23. View abstract.
Paraskevas S, Rosema NAM, Versteeg P, Van der Velden U, Van der Weijden GA. Chlorine dioxide and chlorhexidine mouthrinses compared in a 3-day plaque accumulation model. J Periodontol. Aug;79(8):-400. View abstract.
Shinada K, Ueno M, Konishi C, et al. Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial. Trials. Feb 12;11:14. View abstract.
Valente JH, Jay GD, Zabbo CP, Reinert SE, Bertsch K. Activated chlorine dioxide solution can be used as a biocompatible antiseptic wound irrigant. Adv Skin Wound Care. Jan;27(1):13-9. View abstract.
Zirwas MJ, Fichtel J. Chlorine Dioxide Complex Cleanser: A New Agent With Rapid Efficacy for Keratosis Pilaris. J Drugs Dermatol. May 1;17(5):554-556. View abstract.
Chlorine dioxide is a strong anti-infectious agent. It is antibacterial, antiviral, and can help improve oral health. Read more to learn about the health benefits and side effects of chlorine dioxide.
Chlorine dioxide (ClO2) is a yellow-green gas that was discovered in . Since the early s, people have been using it as a disinfectant [1, 2].
Chlorine dioxide is an oxidant. This means that chlorine dioxide removes electrons from another compound during a chemical reaction. This activity makes it toxic to many bacteria and fungi [2, 3, 4].
Chlorine dioxide is considered potentially toxic to humans at concentrations higher than 0.8 mg/L. Water purification tablets containing chlorine dioxide are marketed to campers, hikers, and backpackers to sanitize fresh water from rivers or lakes; make sure to carefully follow the instructions on the package if you use these products, and never use more than the recommended quantity per volume.
Chlorine dioxide acts as an oxidizing agent (gains electrons during chemical reactions) and interacts with cell components [5].
By taking electrons from microbes, the microbe’s molecular bonds weaken and the cell breaks apart. This process alters the proteins involved in their structure and decreases enzyme function, thus resulting in the death of the microbe [5].
This attack on many proteins simultaneously prevents the microorganisms from mutating and developing resistance [6].
Chlorine dioxide is frequently used to sterilize water and make it safe to drink. The maximum safe limit for chlorine dioxide in drinking water, according to the EPA, is 0.8 mg/L [7].
Chlorine dioxide gas can go through bacterial cell membranes and cause cell death in the pH range of 3-9 [4, 8].
In lab tests, chlorine dioxide was more effective at inactivating fungal spores than chlorine. It inactivated fungal spores by damaging the cell wall and cell membrane, thus causing the leakage of cell substances and eventually, fungal death [9].
In another study, a chlorine dioxide solution reduced 98.2% of bacteria and fungi in a lab test (E. coli, Staphylococcus, Pseudomonas, listeria, salmonella, Candida albicans, etc) [3].
The antimicrobial properties of chlorine dioxide are used to disinfect food, surgical tools, and more [10, 11, 9].
Xiuyuan supply professional and honest service.
Low concentrations of chlorine dioxide are effective in reducing E. coli present in water. Various chlorine dioxide products can help disinfect water and produce safe drinking water [12].
In a 30-month prospective study, chlorine dioxide-treated water in a hospital decreased Legionella bacteria counts. Additionally, there were no patients that acquired Legionnaires disease during the study [13].
The bacteria on vegetable seed sprouts can cause stomach problems and disease outbreaks. Chlorine dioxide treatment and dry heating eliminated E. coli on radish seeds without damaging the seeds. Thus, it can help with food safety [11].
Chlorine dioxide treated-water significantly reduced Escherichia coli (E. coli) bacteria counts on baby spinach. However, non-culturable cells (bacteria that do not grow or divide) were still present. The treatment did not affect the quality of the baby spinach, but it reduced its photosynthetic abilities [12].
In a pilot study, chlorine dioxide gas disinfected gastrointestinal endoscopes, an instrument used to look at the inside lining of the digestive tract. The gas completely inactivated bacterial cells and disinfected all endoscopes [10].
Chlorine dioxide gas efficiently disinfected and improved air quality indoors after single (0.28L solution, 250 mg/L), double, and triple doses. All three doses reduced indoor bacteria and fungi concentrations, but the double and triple doses had significantly better antimicrobial effects [14].
In another study, a chlorine dioxide-based agent was more effective than hydrogen peroxide at killing bacteria that had enhanced resistance to chemical and radiation disinfection (B. pumilus SAFR-032 and Bacillus subtilis ATCC ). Chlorine dioxide can help sterilize peroxide- and UV-resistant spores in hospital environments [15].
In another study, chlorine dioxide decontaminated known pathogens that can cause infections in a hospital room. Although each hospital room had lower bacteria counts, 2 cleaning cycles failed to completely inactivate all harmful organisms [16].
In a week-long study (DB-RCT) of 15 subjects, a mouthwash containing chlorine dioxide decreased bad breath (more than the placebo). It also reduced the number of chemical compounds with distinct bad smells (hydrogen sulfide, methyl mercaptan, and dimethyl sulfide) [17].
The chlorine dioxide mouthwash also reduced plaque and bacteria that cause gum disease (Fusobacterium nucleatum) in saliva [17].
In another study (TB-RCT) of 25 healthy subjects, mouthwash containing chlorine dioxide was as effective as an antibacterial mouthwash (chlorhexidine). There was no significant difference in plaque concentration or bacteria count. Although the chlorhexidine mouthwash initially had a lower bacteria count, there was no statistically significant difference [18].
Chlorine dioxide may also help whiten teeth. It was faster at whitening cow teeth than hydrogen peroxide. However, since it has a low pH, long-term exposure may harm teeth [19].
A 5% chlorine dioxide solution can also help clean the mouth during root canals due to its antimicrobial properties [4].
Chlorine dioxide mouthwashes are available for purchase. If you use one, take special care not to swallow the solution, as the concentration of chlorine dioxide in these products is much higher than the threshold for safe consumption.
Chlorine dioxide is also antiviral. It destroys the proteins on the outside of viruses and degrades the virus [20].
Chlorine dioxide gas is effective against [21]:
Chlorine dioxide solution also inactivated human and monkey rotaviruses (that cause diarrhea) and hepatitis A [22, 23].
Normally, exposure to low amounts of chlorine dioxide is safe for humans. In a study of 17 dialysis patients, 1 month of exposure to chlorine dioxide-treated water did not have any toxic effects or cause anemia (low red blood cell levels) [24].
However, in rats, chlorine dioxide gas altered the structure of blood cells and prevented DNA formation in several organs. The changes in blood cells caused mild hemolytic anemia, a condition in which blood cells are destroyed and removed before their normal lifespan is over [25].
Additionally, an oral dose of 14 mg in rats damaged proteins in their brain cells, demonstrating a potential for neurotoxicity [26].
Chlorine dioxide products also tend to contain high levels of impurities (reactants with additional compounds). These products are useful for wastewater treatment but dangerous when in contact with humans or food [27].
Impurities are mainly caused by other chlorine compounds, such as chlorine and chloroxy anions (ClO2- or ClO3-). They can react with organic matter to form trihalomethane, a compound that causes cancer (carcinogen) [25].
There are only a few human studies available on the effects of chlorine dioxide.
People with G6PD deficiency may have a higher risk of developing anemia due to chlorite exposure from chlorine dioxide [24].
Chlorine dioxide is unstable as a gas and is explosive in concentrations greater than 10%. It can be ignited by almost any form of energy, including sunlight and heat [28, 29].
Chlorine dioxide is toxic and can burn or severely irritate the skin and eyes in high concentrations [30].
The Occupational Safety and Health Administration states that the highest exposure to chlorine dioxide in the air should be 0.1 ppm and 0.3 mg/m3 [31].
Drinking water containing more chlorine dioxide than the toxic threshold (0.8 mg/L) may cause kidney damage [32].
Diclofenac is a drug that treats pain, arthritis, and migraines (NSAID). In water, chlorine dioxide can degrade diclofenac. While this is beneficial during water treatment (preventing trace amounts of drugs from persisting in drinking water), its effects on the human body are unknown [33].
Chlorine dioxide can be found in a gaseous, liquid, or solid state [34, 30, 35].
The best way to store chlorine dioxide is as a liquid/ dissolved gas at 4ºC. Chlorine dioxide cannot be stored for too long, because it slowly separates into chlorine and oxygen [36].
Miracle Mineral Solution is a product that contains sodium chlorite, which reacts with an acid (like lemon juice) to form chlorine dioxide. The creator claimed that it can cure AIDS, cancer, hepatitis, malaria, and autism [37].
If it sounds like snake oil to you, you’d be right. MMS is considered wildly unsafe and has been reported to cause [37]:
In one case, a patient developed Kikuchi-Fujimoto disease after drinking an unknown amount of the miracle mineral solution. The solution triggered an inflammatory response and caused fever, night sweats, and swollen lymph nodes [37].
If you want to learn more, please visit our website Chlorine Dioxide Liquid.