Fluid dispensing is the process of delivering controlled amount of liquids or adhesives in manufacturing or processing applications. Common accessories such as applicators, pumps and controllers ensure that the right amount of fluid is dispensed at the exact location, at the right time.
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Whether manual, semi-automated or fully automated, selecting the right fluid application system depends on several factors:
“Selecting the right fluid application system is not just about technology; it’s about understanding the unique needs of each operation,” says Schnapp. “We engage closely with our clients, ensuring that we find the perfect balance between cost, speed, and precision.”
In any fluid dispensing process, the accessories you choose are instrumental in determining the efficiency, precision, and overall quality of your output. It’s not just about finding tools that fit the job; it’s about understanding the complexities of your specific application.
From the materials used to the production volume, precision requirements, and the ongoing maintenance and durability of these tools, numerous factors come into play. The following sub-sections will delve into these essential considerations:
By carefully assessing these questions, you can select the accessories that are tailor-made for your process, ensuring optimal performance and long-term success.
The world of fluid dispensing is vast and complex, with countless applications across various industries. While off-the-shelf accessories might suffice for standard processes, unique and specialized applications often demand a custom touch. This is where the importance of custom solutions and prototyping comes into play.
“Every customer has unique challenges and requirements. Our goal at Designetics is to transform those specific needs into tangible solutions through innovation and custom design. It’s not just about selling products; it’s about crafting the perfect tools for each job,” says Schnapp.
The advantages of opting for custom solutions go beyond mere compatibility. They can lead to:
“Our team of experts specializes in custom-designed accessories. We don’t just provide a product, we offer a partnership. We work closely with you at every step to craft a solution that’s perfectly aligned with your goals,” said Schnapp.
By asking these questions, you can make an informed decision about the fluid dispensing accessories that will best suit your operational needs and deliver the most value. Remember, the right accessories can significantly enhance your manufacturing process, leading to increased productivity, precision, and overall operational efficiency. Armed with the right questions, you’re on the path to making the best choice for your fluid dispensing needs.
“At Designetics, our mission goes beyond providing top-tier accessories. We believe in partnering with our clients, guiding them every step of the way to ensure they make the best choices for their unique fluid dispensing needs. Your success is our success,” says Schnapp.
Automated fluid management systems have gained a lot of popularity in the recent past. Production processes in biopharma have never been more competitive. New advances and research in gene and antibody therapy have called for more streamlined production steps.
An important factor is safe and efficient fluid handling, which is still often carried out manually. This does not only leave more space for human errors, it can also affect staff and patient safety. Automated fluid management systems, in combination with single-use technologies, help to reduce product loss and rid medical staff of monotonous and laborious tasks like pipetting.
However, as not every fluid management system is the same in terms of production yields and functions, there are several considerations to be taken into account. Here are seven questions you should ask to make the right choice.
A fluid management system (FMS) serves as an automated solution in the handling of sensitive fluids which have to be protected from contamination. FMS are used in different industries and have proven to be especially valuable for aseptic fluid management processes in biopharma production and therapeutic treatments.
The advanced technology automates different steps (or the complete process) of the workflow, which had to be carried out manually by healthcare professionals in the past. Different case studies have shown that automated systems are able to reduce the risk of human errors and, consequently, product loss.
Sterile connectors in automated aliquoting systems ensure that fluids are not exposed to any contaminating factors during filling into containers or fluid controls.1
Due to the specifics of each individual projects, the components needed for a liquid handling can vary. Whereas in antibody production for biopharmaceuticals, freezing and filtration is often part of the process due to transport or conservation purposes, this is seldom the case in diagnostics.
Let us start with a homogenization solution, like RoSS.PADL. This system is able to cool and homogenize substances simultaneously in single-use bags, allowing for optimal temperatures during draining. For aseptic filling in a closed system, the essential components include pumps, valves, and single-use assemblies, seamlessly integrated into a filling system. To achieve the desired storage temperature, freezing solutions like our plate freezer or a cryogenic freezer like RoSS.LN2F are required.
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It is also possible to combine several platforms to achieve end-to-end solutions through seamless integration.
There are different fluid handling systems, designed for a variety of volumes. Liquid handling is an important part of life sciences and needed in biotechnological and pharmaceutical production practices, as well as in research and diagnostics. Depending on the subject, such as clinical diagnostics or drug discovery, fluid volumes vary.
Due to an increase in clinical assays for research and diagnostics, not only connected to the recent Covid-19 pandemic, but new advances in antibody research in general, the demand for low-volume technologies has grown rapidly.
Further, especially in larger-scale pharmaceutical companies and contract development and manufacturing organizations (CDMOs) that carry out low-volume and high-volume projects, a need for scalability has sparked. Scalable fluid management systems like RoSS.FILL address this need with a combination of single-use bags in different sizes and automated aseptic filling methods that can easily be adjusted to individual project demands.
Due to the specifics of each individual projects, the components needed for a liquid handling can vary. Whereas in antibody production for biopharmaceuticals, freezing and filtration is often part of the process due to transport or conservation purposes, this is seldom the case in diagnostics.
Let us start with a homogenization solution, like RoSS.PADL. This system is able to cool and homogenize substances simultaneously in single-use bags, allowing for optimal temperatures during draining. For aseptic filling in a closed system, the essential components include pumps, valves, and single-use assemblies, seamlessly integrated into a filling system. To achieve the desired storage temperature, freezing solutions like our plate freezer or a cryogenic freezer like RoSS.LN2F are required.
It is also possible to combine several platforms to achieve end-to-end solutions through seamless integration.
Fluid management requires a lot of staff, especially in laboratory settings. The tasks are rather monotonous and laborious, requiring staff to spend a lot of time hunched over with pipettes and syringes during manual liquid handling. Automating these processes allows workers to spend their time on other tasks and streamlining the overall process in general.
Most important for the production of high-quality drugs and assays is the reduction of human error through automated liquid handling systems. They reduce contamination and deliver consistent results. Additionally, integrated fluid control systems ensure quality and safety against distention during insertion while reducing product loss.
There are also solutions that support staff during procedures in the operating room. For example, fluent fluid management systems with integrated touchscreens, tubes and waste-bags or suction canisters, which are used in hysteroscopic procedures, help health workers monitor fluids when tissue is removed.
Automated systems are designed to be user-friendly, however, it is still necessary to brief staff how to use these systems (i.e. the inserting of tubes), as software and calculation tools need explaining in order to work efficiently. In many cases, there are webinars, on-site trainings, and other instruction materials available.
As mentioned before, there are various systems for different production sizes available. However, project demands might change over time. If an increase in production is needed, as we encountered with fluid management solutions in vaccine production during the recent pandemic, for example, scalability becomes important to prevent bottlenecks.2
In response to this need, Single Use Support's fluid management solutions are designed to be adaptable for both scale-up and scale-out requirements, accommodating various bag sizes.
The concept of "scale-up" is exemplified in scenarios like FDA approval, where there is a need to produce more drug substance efficiently using larger bags. On the other hand, "scale-out" is relevant in applications such as gene therapy and viral vector production, where more liquids are required, leading to the use of multiple bags.
In order to comply with aseptic production regulations, it is necessary to ensure that fluids are not exposed to contamination. The safest way to do so is by linking different process steps with each other. Therefore, it is important that fluid management systems are connectable with cryogenic freezers or homogenizers, for instance, without breaking the cold chain or exposing substances to contamination.
For this reason, solutions by Single Use Support are designed to address the problem of interoperability: Aseptic bag filling machines like RoSS.FILL are compatible with protective cases for all available 2D and 3D single-use bags or bottles. Once bags are filled in their protective shell, the racks can easily be transferred into RoSS.pFTU, a fully scalable and automated plate-freezer and thawing system.
Single Use Support fluid management solutions have been designed to meet the rising standards in biopharma, due to new advances in life sciences and drug manufacturing. As gene and cell therapeutics require special production standards and high adaptability, there is a need for customizable and flexible processing solutions.
Even though it might not seem obvious at first, by optimizing the supply chain with single-use products, sustainability of production processes can be increased, as less energy has to be used for extensive cleaning, and product loss can be minimized.
cGMP compliant filling and draining machines like RoSS.FILL are adjustable for up-and-down-scaling and extremely flexibility. The system is compatible with single-use bags or bottles in different sizes, allowing for seamless aseptic filling and transferring into plate-freezers and transport containers, which keep sensitive substances at the required temperatures. Supporting devices like RoSS.PADL knead single-use bags gently and cool them during homogenization of the processed fluids.
With such solutions, Single Use Support helps biopharmaceutical manufacturers in streamlining their production processes, making them more efficient, sustainable and safe.
Contact us to discuss your requirements of Electro Pneumatic Valve. Our experienced sales team can help you identify the options that best suit your needs.